Type 1 diabetes preventive treatment

Hello,

I was recently told about a drug called Teizeild (Teplizumab) that acts by inhibiting the immune system to delay the onset of type 1 diabetes in people over 8 years of age.

They have proposed to me to enter a clinical trial to see if my children have antibodies against the pancreas, and if they do, to monitor them intensively so that, only if at some point a minimal glycemic dysregulation appears, apply the treatment and delay the onset of diabetes by an average of 4 years.

This drug is already approved in the US, the United Kingdom, Canada and China.

Does anyone have experience with this trial or this drug?

I would have loved a drug like this before my debut, so if I can help my children it would be wonderful.Although it is much better that they do not need the drug!

In theory, if you are diabetic, your children have only an 8% chance of having it.It's quite little I think.

If both parents have it, then they have 30%, so it might be fine.

Thanks for your response.

I am aware that it is unlikely that they are diabetic, in fact if the screening comes back negative I will be happier than if they are given the drug.

The thing is that if we can detect people at risk and give them preventive treatment, I think this can be one of the biggest changes in the management of diabetes.We already have a thousand insulins and technology for when there is no turning back, this is for when there is still something to do...

Although like everything new, you have to take it with great caution and see how the issue progresses.

Sherpa41 said:
@Sherpa41 said:

In theory, if you are diabetic, your children have only an 8% chance of having it.It's quite little I think.

If both parents have it, then they have 30%, so it might be fine.

Phew, the odds are 50%.

I do not have any diabetic family member, of any kind in several generations and I am T1D with a probability of 0.07%.

I would say ok to the study, better safe than sorry.

Thanks for your comment.

The truth is that it seems somewhat promising... we'll see.I will inform you how the study progresses.

All the best!

Ruthbia said:
@Ruthbia said:

Phew, the odds are 50%.

I do not have any diabetic family member, of any kind in several generations and I am T1D with a probability of 0.07%.

I would say ok to the study, better safe than sorry.

They are immunomodulatory drugs, they modulate the immune system but are not immunosuppressive.It is a new field and the truth is that it could be very beneficial for many autoimmune pathologies.For me, after 43 years of db, I don't think so, but it is good if they have offered it to you.In my case, no one is known to have db type 1, but I know several families with several members of db type 1. Specifically, in one family, the mother and the three daughters debuted one after the other, and in another family, two teenage brothers, one first and the other later.I met them at the bomb course.Yes, there is a family tendency, it is not as little as it is said.I would do it.Because delaying the onset also implies later trying to maintain the insulin reserve as much as possible.If you save 10 years, they are good.

Buenos días, voy a actualizar un poco este tema.

Finalmente le hicieron el cribado a mis hijos y salieron negativos para los 4 anticuerpos que analizan. Una alegría y un poco menos de la culpa anticipatoria que tenía encima (ya sé que la probabilidad era muy baja, pero la preocupación era muy alta… qué le vamos a hacer!).

Pero a lo que nos importa a todos, resulta que este fármaco va teniendo resultados interesantes (aunque los estudios siguen siendo de muy pocos pacientes):

• En niños con 2 o más anticuerpos positivos, se administra cuando ya hay disregulación glucémica pero todavía no cumplen criterios de diabetes tipo 1. Hay algún caso en el que a los 7 años de la dosis única del fármaco siguen sin progresar a diabetes tipo 1. En cambio los que reciben placebo debutan al cabo de 2 años.
• Ahora en EEUU se ha aprobado su uso para niños con debut de diabetes tipo 1 reciente para ralentizar la progresión de la destrucción pancreática y mantener la producción propia de insulina más tiempo. Faltará ver qué resultados reales tiene esto en el control de la enfermedad, pero si se mantiene la función del páncreas más tiempo puede ser una enfermedad más fácil.

Entiendo que estos avances son lentos porque los estudios se hacen con pocos casos y se siguen los pacientes durante varios años, pero me sigue pareciendo esperanzador. Puede que con el tiempo se puedan ir administrando dosis repetidas cada X años y así evitar la progresión, quien sabe. Y aunque a nosotros nos llegue tarde, bienvenido sea cualquier avance preventivo entre comillas.